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KMID : 1145520200060020088
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Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 2 p.88 ~ p.96
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Recent progress in selective bioconjugation
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Rajkumar Subramani
Bhise Abhinav
Bobba Kondapa Naidu
Yoo Jeong-Soo
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Abstract
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Selective installation of proteins using chemical reagents is important for the development of potential biomaterials for the treatment of human diseases. However, modification in a chemo- and regioselective manner under physiological conditions is a great challenge due to the presence of multiple reactive centers in the protein. Currently, the majority of conjugations are limited to lysine (Lys)- and cysteine (Cys)-selective reagents. Thus, they have been extensively studied. Apart from Lys and Cys, widespread site selectivity has been recently achieved through most of the 20 naturally occurring amino acid-bearing reactive functional groups. Consequently, this review focused on several recent achievements in site-selective modification of the rarest amino acid backbones (e.g., methionine, serine, glutamic acid, and tyrosine).
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KEYWORD
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bioconjugation, antibody, chemoselective, site-selective
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